The MAOA Gene, Brunner’s Syndrome, and Violence: A Societal Call to Action

Understanding Brunner’s Syndrome and the MAOA Gene

Brunner’s syndrome is a “rare” genetic disorder caused by a mutation in the monoamine oxidase A (MAOA) gene. This gene is crucial for breaking down neurotransmitters like serotonin, norepinephrine, and dopamine. When the MAOA gene is mutated, it leads to a deficiency in the MAOA enzyme, resulting in behavioral abnormalities, including impulsive aggression and cognitive impairments.

While Brunner’s syndrome itself is rare, certain variants of the MAOA gene, particularly the low-activity variant known as MAOA-L, are more common. Studies suggest that around 30–40% of men in some populations carry the MAOA-L variant. This variant has been linked to a higher propensity for aggressive behavior under specific environmental conditions. However, carrying the MAOA-L variant does not equate to having Brunner’s syndrome, which is often used by patriarchal-led science to downplay the broader implications.

The Societal Impact of Genetic Predispositions and Violence

The connection between genetic predispositions like the MAOA-L variant and violent behavior is complex, involving an interplay of genetics, environmental factors, and…